| ncRNA name | ILK siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cells |
| Methods | siRNA transfection, transwell assay, adhesion assay, ELISA, qPCR, RT-PCR |
| Expression pattern | associated |
| Functional description | We found that hypoxia strongly induced the expression of ILK, HIF-1α, SDF-1, and VEGF. Moreover, the silencing of ILK attenuated their expression. It also decreased the phosphorylation of protein kinase B (PKB/AKT) and extracellular regulated protein kinases (ERK) and nearly abolished the proliferation, migration, and adhesion of EPC to RPE cells. |
| PubMed ID | 29610861 |
| Year | 2018 |
| Title | Integrin-Linked Kinase Controls Choroidal Neovascularization by Recruitment of Endothelial Progenitor Cells. |
| Drug-related ncRNA | NO |
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